I have always rather liked the Demon Queen of Spiders. Sure she is totally the bad girl cliche, but I am only human.
Others share my love it seems and have also played on the Lolth/Lilith connection some.
Mythopoeic Ramblings has some good material on the Spider Queen, http://mythopoeicrambling.blogspot.com/2011/10/respinning-demon-queen.html
Lawful Indifferent also give us their take, http://lawfulindifferent.blogspot.com/2011/10/lolth-spider-bitch-of-abyss.html